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Medical· 2 min read

Hepatology

Non-alcoholic fatty liver disease and its more aggressive form, non-alcoholic steatohepatitis (NASH), has become the fastest-growing cause.

Hepatology


Fatty Liver Diseases

Non-alcoholic fatty liver disease and its more aggressive form, non-alcoholic steatohepatitis (NASH), has become the fastest-growing cause for liver transplantation among young Americans, according to a recent study.

Typically, older adults experience slow progression of fatty liver disease unrelated to alcohol, which can eventually lead to liver cirrhosis. However, due to rising obesity, hypertension, and diabetes, younger people are progressing to end-stage liver disease within their lifetime.

In Texas, in particular, non-alcoholic steatohepatitis is the #1 indication for liver transplantation in adults. It affects 1 in 3 adults and 1 in 10 children.

The best treatment is prevention. It is important to identify fatty liver damage early and then focus on controlling blood pressure, diabetes, weight loss, and a healthy lifestyle to better help patients with fatty liver disease.


A unique synthetic compound D-PDMP, the brainchild of American scientists, is capable of stopping hair loss, discoloration, and skin inflammation. It inhibits the synthesis of glycosphingolipid fats involved in activating inflammatory processes, reports "Lenta.RU". According to specialists, in rodents whose diet is rich in fats and cholesterol, signs of skin aging appear early.
But D-PDMP can counteract the negative effects of fats. In the experiment, scientists divided the test rodents into groups. One group, starting at 12 weeks of age, was fed food rich in fats and cholesterol, while the second received regular food. The former began to show signs of skin aging, including hair loss and the appearance of inflammation foci.
From 20 weeks of age, the rodents began receiving D-PDMP. It turned out that doses of 1 to 10 milligrams per kilogram of body weight significantly improved skin condition over 16 weeks. Furthermore, skin cells showed reduced levels of lactosylceramide glycosphingolipid, which activates inflammatory reactions. The findings of the study are also relevant to humans, scientists believe.
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