Sucralose — a Popular Sugar Substitute — Turns Out to Be More Dangerous Than Thought
University of North Carolina: sucralose forms fat-soluble metabolites that linger in tissues and reduces the amount of beneficial bacteria in the gut.
University of North Carolina: sucralose forms fat-soluble metabolites that linger in tissues and reduces the amount of beneficial bacteria in the gut.
It was considered safe and not to accumulate in body tissues. However, the latest research from the University of North Carolina suggests the opposite. It is metabolized into at least two fat-soluble compounds.
This was established in an experiment with rats. The animals were given sucralose at a dose of 80.4 milligrams per kilogram of body weight per day for 40 days. Urine and stool samples were collected for analysis. They were analyzed not only for 40 days but also for two more weeks. At the very end, fat-tissue samples were also taken for analysis.
It turned out that sucralose metabolites were detected in urine 11 days after stopping the sweetener and six days after traces of sucralose itself were no longer detectable in the body. The metabolites belonged to acetylated compounds, which readily dissolve in fat. This means they are more likely to remain in the body.
In addition, sucralose itself was found in fat tissue two weeks after the end of intake. So the sweetener can stay in the body for a long time and may be passed to children through breastfeeding. There is also reason to believe that sucralose reduces the presence of beneficial bacteria in the gut.
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