Dermatology

Dermatology

A medication has been approved for treating cases of psoriasis in adolescents that are resistant to conventional therapy

USTEKINUMAB – STELARA

The first two subcutaneous injections are given 4 weeks apart, followed by maintenance therapy every 12 weeks.

(Janssen Biotech)

Researchers at Moscow State University have studied aging and its effect on key cellular processes (autophagy, the work of mitochondria — "the cell's power plants" — and oxidative stress), reports "Lenta.RU". At the same time, promising methods for treating age-related kidney failure were announced. It is known that during autophagy cells break down and recycle their damaged components. It is activated in certain types of acute kidney failure, sepsis and ischemic kidney disease.
As the body ages, the efficiency of autophagy decreases. As a result, oxidized proteins and damaged cell components, including mitochondria, accumulate. Consequently, the kidneys of elderly people accumulate defective proteins, lipids, nucleic acids and various cellular organelles.
It has been proven that calorie restriction (fasting dietary therapy) activates autophagy and reduces age-related pathological changes in the kidney. For example, a short-term 30–40% reduction in food intake over several weeks can increase the kidney's resistance to acute kidney failure. There are also drugs that mimic calorie reduction (rapamycin).
Scientists are also pinning hopes on therapies aimed directly at mitochondria. It is no secret that in acute kidney failure even the mitochondria of a young body are severely damaged, and aging itself leads to mitochondrial dysfunction. From this perspective, mitochondria-targeted antioxidants have shown promise — the specific mitochondrial ROS scavenger (Mito TEMPO), SS-31 peptides and compounds from the SkQ group developed at Moscow State University.